Protective Effects of Lantana camara (aculeata) in Rheumatoid arthritis using in vitro and in vivo Complete Freund’s Adjuvant induced arthritis in rats

The main objective of the present work is to evaluate potential Lantana camara (aculeata) for anti-arthritic activity using in vitro and vivo study. L. an important medicinal, ornamental, essential oil-producing herb from family Verbenaceae. Different parts have been used treatment various human ailments such as itches, cuts, ulcers, swellings, bilious fever, eczema, tetanus, malaria, tumor, rheumatism, headache. activities pet ether, ethyl acetate, ethanol, aqueous extracts were initially evaluated model arthritis. ethanolic found be better among all extract study hence subjected further complete Freund’s adjuvant (CFA) rats 28 days. Both at 200 400 mg/kg different parameters. paw volume displacement, changes body weight, arthritic index, alteration serum biomarker, hematological parameters, secondary lesions noticed radiograph, histopathology measured a mark antiarthritic activity. results indicate that protects remarkably against primary lesions, weight changes, biomarker radiological, histopathological, perturbations induced by CFA dose-dependent manner. However, effect dose was more significant, superior, pronounced than also it comparable standard drug.